Table 2.
Cox regression models for the association between HDL subfractions and MACCEs risk.
| Variables | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| HDL | ||||||
| Low | Reference | Reference | Reference | |||
| Medium | 1.04 (0.70–1.54) | 0.861 | 0.95 (0.64–1.41) | 0.796 | 1.03 (0.69–1.54) | 0.888 |
| High | 0.75 (0.48–1.16) | 0.193 | 0.57 (0.36–0.89) | 0.014 | 0.64 (0.40–1.02) | 0.060 |
| P for trend | 0.212 | 0.015 | 0.066 | |||
| Per 0.1 mmol/L increase | 0.97 (0.90–1.04) | 0.357 | 0.93 (0.86–0.99) | 0.043 | 0.95 (0.88–1.02) | 0.151 |
| HDL-2b | ||||||
| Low | Reference | Reference | Reference | |||
| Medium | 0.71 (0.46–1.07) | 0.100 | 0.61 (0.40–0.93) | 0.023 | 0.68 (0.45–1.04) | 0.078 |
| High | 0.83 (0.55–1.25) | 0.370 | 0.58 (0.38–0.88) | 0.010 | 0.65 (0.43–1.00) | 0.050 |
| P for trend | 0.336 | 0.010 | 0.047 | |||
| Per 0.1 mmol/L increase | 0.92 (0.78–1.10) | 0.373 | 0.81 (0.68–0.97) | 0.020 | 0.86 (0.72–1.03) | 0.093 |
| HDL-3 | ||||||
| Low | Reference | Reference | Reference | |||
| Medium | 0.56 (0.37–0.83) | 0.004 | 0.62 (0.42–0.93) | 0.022 | 0.76 (0.50–1.14) | 0.186 |
| High | 0.43 (0.28–0.68) | <0.001 | 0.48 (0.31–0.75) | 0.001 | 0.58 (0.37–0.91) | 0.019 |
| P for trend | <0.001 | <0.001 | 0.016 | |||
| Per 0.1 mmol/L increase | 0.72 (0.61–0.85) | <0.001 | 0.76 (0.65–0.90) | 0.001 | 0.83 (0.70–0.98) | 0.028 |
HR with 95% CIs were estimated using both tertile-based and continuous models, with the lowest tertile serving as the reference category. HRs for each 0.1 mmol/L increment were additionally calculated.
Model 1: unadjusted.
Model 2: adjusted for age and sex.
Model 3: adjusted for age, sex, hypertension, diabetes mellitus, CKD, and statin use.