TABLE 2.
Antibody titers induced by immunization with DNA vaccine vectors
| Immunization vectora | Antibody titers with the following coating antigenb:
|
|||
|---|---|---|---|---|
| Family 1
|
Family 2
|
|||
| PspA1 (St 435/96) | PspA2 (St 371/00) | PspA3 (St 259/98) | PspA4 (St 255/00) | |
| Saline | 1:160 | 1:160 | 1:160 | 1:160 |
| pTG-pspA1 | 1:10,240 | 1:1,280 | 1:40 | 1:320 |
| pTG-pspA2 | <1:20 | 1:20 | 1:40 | 1:20 |
| pTG-pspA3 | 1:20 | 1:20 | 1:1,280 | 1:1,280 |
| pTG-pspA4 | 1:20 | 1:20 | 1:80 | 1:160 |
| pTG-pspA1/4 | 1:10,240 | 1:640 | 1:160 | 1:2,560 |
| pTG-pspA3/2 | 1:20 | 1:640 | 1:10,240 | 1:5,120 |
a
Sera were obtained from mice that were immunized with the DNA vaccine vectors or injected with only saline.
b
ELISA plates were coated with PspAs purified from the pneumococcal strains.