TABLE 1.
Antigen | Adjuvant | Immunization
|
Neutralizing titer | Anti-C. trachomatis MoPn ELISA titera
|
|||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Route | No. of times | IgM | IgA | IgG | IgG1 | IgG2a | IgG2b | IgG3 | |||
MOMP | CpG + alum | i.m. + s.c. | 1 | 450 | <100 | 800 | 51,200 | 25,600 | 25,600 | 12,800 | 200 |
Ovalbumin | CpG + alum | i.m. + s.c. | 1 | 0 | <100 | <100 | <100 | <100 | <100 | <100 | <100 |
MOMP | CpG + alum | i.m. + s.c. | 3 | 450 | <100 | 1,600 | 102,400 | 25,600 | 25,600 | 1,600 | 400 |
Ovalbumin | CpG + alum | i.m. + s.c. | 3 | 0 | <100 | <100 | <100 | <100 | <100 | <100 | <100 |
C. trachomatis MoPn | i.n. | 1 | 1,250 | <100 | 3,200 | 25,600 | 3,200 | 25,600 | 12,800 | 3,200 |
ELISA, enzyme-linked immunosorbent assay.