Table 2.
Type of Grade 3 or above toxicity. Gx: grade of toxicity at x level, NR: not recorded.
| Number | Acute |
Late |
Type of toxicity | Grading scale | |||||
|---|---|---|---|---|---|---|---|---|---|
| G3 | G4 | G5 | G3 | G4 | G5 | ||||
| Yamaguchi [16] | 12 | 3 | 1 | 0 | 2 | 0 | 1 | Acute: oesophageal perforation G3 (2), radiation oesophagitis (G3 (1), oesophageal perforation G4 (1). Late: oesophageal stenosis G3 (1), oesophageal perforation G3 (1), oesophageal haemorrhage G5 (1) |
CTCAE v3 |
| Kim [17] | 10 | 0 | 0 | 3 | 0 | 0 | 0 | Acute: oesophageal perforation and trache-oesophageal fistula G5 (3) | CTCAE v3 |
| McAvoy [34] | 1 | NR | NR | NR | 0 | 1 | 0 | Late: trache-oesophageal fistula G4 (1) | CTCAE v4 |
| Griffioen [33] | 1 | NR | NR | NR | 1 | 0 | 0 | Late: radiation oesophagitis G3 (1) | CTCAE v4 |
| Kilburn [26] | 1 | NR | NR | NR | 0 | 0 | 1 | Late: oesophageal haemorrhage G5 (1) | CTCAE v4 |
| Binkley [28] | 38 | NR | NR | NR | 1 | 0 | 0 | Late: radiation oesophagitis G3 (1) | CTCAE v4 |
| Katano [18] | 4 | 0 | 0 | 0 | 1 | 0 | 0 | Late: dysphagia G3 (1) | CTCAE v4 |
| Hong [5] | 39 | 0 | 0 | 0 | 3 | 0 | 0 | Late: trache-oesophageal fistula G3 (3) | CTCAE v4 |
| Zhou [19] | 55 | NR | NR | NR | 0 | 0 | 11 | Late: oesophageal perforation and trache-oesophageal fistula G5 (11) | CTCAE v3 |
| Chen [20] | 36 | 19 | NR | NR | NR | 7 | NR | Acute: radiation oesophagitis/dysphagia G3 (19) Late: oesophageal haemorrhage/tracheoesophageal fistula G4 (7) |
Not recorded |
| Schlampp [22] | 62 | NR | NR | NR | 1 | 1 | 0 | Late: oesophageal stenosis G3 (1), tracheoesophageal fistula G4 (1) | CTCAE v4 |
| Total (%) | 22 (38.6) | 1 (1.8) | 3 (5.3) | 9 (15.8) | 9 (15.8) | 13 (22.8) | Perforation/TOF: 30 Oesophagitis/dysphagia: 23 Bleeding: 2 Stenosis: 2 |
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