TABLE 2.

Sensitivity to INH and catalase-peroxidase activities of M. tuberculosis strain INH34 transformed with plasmids bearing different katG alleles and of the reference strain M. tuberculosis H37Rv

M. tuberculosis strain	katG genotype	Catalase activitya	Peroxidase activitya	MIC of INH (μg/mL)
H37Rv	WTb	3.81 ± 0.17	0.11 ± 0.005	0.05
INH34-pAP01	ΔkatG	NDc	ND	>10
INH34-pPD28	WT	1.87 ± 0.26	0.054 ± 0.002	0.1
INH34-pAP21	T275P	ND	ND	>10
INH34-pAP22	A139V	1.96 ± 0.44	0.043 ± 0.003	0.1
INH34-pAP23	S315T	1.66 ± 0.18	0.046 ± 0.001	5

^aMean activity in whole-cell protein extracts in units per minute per milligram ± standard deviation from three experiments.

^bWT, wild type.

^cND, not detected.