Table 3.

Summary of significant sub-acute effects of Cannabis sativa extract

Category	Parameter	Direction of change	Dose(s) affected	Significance level
Body/Organ weight	Body weight	↓	250 mg/kg	P<0.05
	Pancreas wt	↓ vs control	250 mg/kg	P<0.01
Liver function	ALP	↓	25 mg/kg	P<0.05
	ALT	↓	25 & 250 mg/kg	P<0.05
	AST	↑	25 & 125 mg/kg	P<0.05–0.01
Renal/metabolic	Urea	↑	250 mg/kg	P<0.05
	Glucose	↑	125 & 250 mg/kg	P<0.01
	LDH	↑	all doses	P<0.01
	CK	↓	125 & 250 mg/kg	P<0.01
Lipids	TAG	↓	250 mg/kg	P<0.01
	LDL	↓	250 mg/kg	P<0.05
Haematology	PCV	↑	250 mg/kg	P<0.05
	Hb	↑	125 mg/kg	P<0.05
	PLT	↑	125 mg/kg	P<0.01
	MCHC	↓	all doses	P<0.05–0.01
	WBC	↓	125 & 250 mg/kg	P<0.05–0.01
	Lymphocytes	↓	125 & 250 mg/kg	P<0.01
	Neutrophils	↑	all doses	P<0.05–0.01
	Monocytes	↑	all doses	P<0.01