Table 2. Variables measured at 24 weeks’ antiretroviral therapy (ART) associated with the changes in HIV reservoir markers between 24 and 156 weeks of ART^*.

Variable	Total HIV DNA†		Intact HIV DNA		Defective HIV DNA
	Effect size (95% CI)	p‡	Effect size (95% CI)	p	Effect size (95% CI)	p
Age, per year	–2.99 (−28.5 to 22.5)	0.60	–0.49 (−5.00 to 4.02)	0.86	1.19 (−14.3 to 16.7)	0.66
NRTI backbone, ABC+3 TC vs. FTC +TDF/TAF§	–1.10 (−4.80 to 2.60)	0.56	–0.67 (−4.56 to 3.22)	0.74	2.67 (−0.94 to 6.27)	0.15
IFN-γ release, per pg/mL	2.40 (−13.2 to 18.0)	0.79	–1.32 (−4.04 to 1.40)	0.59	–5.29 (−14.4 to 3.81)	0.14
CD8+ T-cell reactivity, per %	–537 (−1677 to 603)	0.27	–85.6 (−298 to 127)	0.25	–361 (−1073 to 351)	0.15
CD8+ T-cell proliferation, per %	62.7 (28.7–96.7)	0.014	2.84 (−4.62 to 10.3)	0.56	37.8 (18.5–57.1)	0.0017

^*Numerical data provided in Table 2—source data 1.

^†Total, intact, and defective HIV DNA are in copies/10⁶ PBMC.

^‡Calculated by fitting generalized linear models (GLM), type III tests were used.

^§Six participants were treated with ABC+3TC and six participants – with FTC+TDF or FTC+TAF as an NRTI backbone.