Appendix 2—table 2. Comparison of models for the virological markers (within-group analysis).
| Dependent variable | Group | Explanatory variables | Intercept only (repeated-measures design) | Intercept + time point | ||
|---|---|---|---|---|---|---|
| Estimate (95% CI) | p * | Estimate (95% CI) | p | |||
| Total DNA (log10 fold change from baseline) |
Intensified group | Intercept | −0.21 (−0.33 to −0.08) | 0.0022 | −0.17 (−0.44 to 0.11) | 0.0016 |
| Time point | - | - | - | 0.40 | ||
| Control group | Intercept | 0.16 (0.05 to 0.27) | 0.0053 | 0.24 (0.01 to 0.48) | 0.019 | |
| Time point | - | - | - | 0.42 | ||
| US RNA (log10 fold change from baseline) |
Intensified group | Intercept | −0.54 (−0.75 to −0.33) | 6.0 × 10–5 | −0.62 (−1.19 to −0.06) | 0.0069 |
| Time point | - | - | - | 0.60 | ||
| Control group | Intercept | 0.05 (−0.26 to 0.37) | 0.73 | 0.24 (−0.44 to 0.92) | 0.71 | |
| Time point | - | - | - | 0.88 | ||
| US RNA/total DNA ratio (log10 fold change from baseline) |
Intensified group | Intercept | −0.47 (−0.67 to −0.27) | 2.2 × 10–4 | −0.53 (−1.09 to 0.03) | 0.029 |
| Time point | - | - | - | 0.59 | ||
| Control group | Intercept | 0.01 (−0.29 to 0.32) | 0.94 | −0.07 (−0.76 to 0.62) | 0.81 | |
| Time point | - | - | - | 0.86 | ||
*
p values were calculated by type III tests of fixed effects.