TABLE 1.
Killing of N. meningitidis by BMMφ
| Timea (h) | No. of CFU (%)b
|
|
|---|---|---|
| WT | SR-A−/− | |
| 2.5 | 431 ± 169 (100) | 76 ± 10* (100) |
| 4.5 | 44 ± 17 (10) | 10 ± 18 (13) |
| 6 | 125 ± 21 (29) | 40 ± 39 (52*) |
a
Time elapsed from addition of bacteria to wells.
b
Results show the mean number of bacteria (CFU) per well when 105 Mφ were infected with MC58 bacteria for 1 h, extracellular bacteria were removed by gentamicin and washing, and then the Mφ were lysed over time to determine the number of associated bacteria. The numbers in parentheses are the percentages of bacteria for those times compared with the number of meningococci obtained at the first time point that could be assessed, 2.5 h. Triplicate conditions from one experiment representative of at least three similar assays are shown.
*
No significant difference (P > 0.05) between WT and SR-A−/− Mφ.