Table 1.
Results of the digital pathology evaluation. The mean value is ± standard deviation.
| Parameter | Study group | Control group | p value | |
|---|---|---|---|---|
| Number of samples (n) | 4 | 4 | ||
| Corneal thickness | Number of measurements (total) | 718 | 812 | |
| Number of measurements per eye (avg) | 179.50 ± 18.52 | 203.00 ± 24.29 | 0.17480‡ | |
| Epithelium thickness (avg total) | 80.47 ± 18.39 | 77.36 ± 11.49 | 0.00010 † | |
| Epithelium thickness (avg of avgs) | 80.20 ± 6.59 | 77.67 ± 4.27 | 0.57160‡ | |
| Minimal epithelium thickness (avg) | 37.51 ± 13.11 | 49.02 ± 2.83 | 0.21180‡ | |
| Maximum epithelium thickness (avg) | 126.67 ± 21.50 | 95.67 ± 3.51 | 0.15430‡ | |
| Max-min difference (avg) | 78.11 ± 47.37 | 63.00 ± 33.51 | 0.50570‡ | |
| Arithmetic Mean Roughness (Ra) | 0.83 ± 0.19 | 0.68 ± 0.21 | 0.18160‡ | |
| Maximum Height of Profile (Rz) | 4.39 ± 1.32 | 2.88 ± 0.73 | 0.04940 ‡ | |
| Corneal thickness distribution | Measurements exceeding 1 σ | 12.53% ± 10.82 | 13.18% ± 18.46 | 0.86530‡ |
| Measurements exceeding 2 σ | 3.90% ± 2.57 | 1.60% ± 3.74 | 0.08000‡ | |
| Measurements exceeding 3 σ | 1.25% ± 1.45 | 0.25% ± 0.57 | 0.23020‡ | |
| Skewness | 0.73 ± 0.98 | -0.43 ± 0.46 | 0.08550‡ | |
| Rolling Standard Deviation | 8.64 ± 2.63 | 4.36 ± 1.25 | 0.06860‡ | |
| Epithelium cells density | Analyzed Area (total) – mm2 | 18.99 | 9.19 | |
| Analyzed Area Mean Per eye (avg) – mm2 | 2.54 ± 3.05 | 1.15 ± 0.08 | 0.4990‡ | |
| Cell density (total) – cells/mm2 | 2205.0 | 6394.0 | ||
| Cell density (avg) – cells/mm2 | 4271.0 ± 2184.0 | 6390.0 ± 762.0 | 0.1683‡ | |
| Stroma cells density | Analyzed Area (total) – mm2 | 45.84 | 48.52 ± | |
| Analyzed Area Mean Per eye (avg) – mm2 | 5.73 ± 0.78 | 6.07 1.38 | 0.6330‡ | |
| Cell density (total) – cells/mm2 | 1272.0 | 548.0 | ||
| Cell density (avg) – cells/mm2 | 2534.0 ± 662.1 | 1082.0 ± 224.0 | 0.0179 ‡ | |
† – unpaired T Test, ‡ – paired T Test. Significance are in bold.