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. Author manuscript; available in PMC: 2005 Nov 14.
Published in final edited form as: J Lipid Res. 2005 Feb 16;46(5):885–895. doi: 10.1194/jlr.M400476-JLR200

Fig. 9.

Fig. 9

Model of trans-10,cis-12 CLA-mediated changes of morphology in adipocytes: transcriptional, translational, and posttranslational regulation of lipid droplet-associated proteins. Under normal, non-lipolytic conditions, perilipin is expressed exclusively in mature adipocytes, serving as a barrier to protect lipid droplets from hydrolysis by lipases such as HSL. Chronic supplementation of trans-10,cis-12 CLA (t10,c12 CLA) changes adipocyte morphology by promoting the development of numerous small lipid droplets coated with ADRP. Trans-10,cis-12 CLA induces perilipin phosphorylation, which drives perilipin movement from the surface of lipid droplets to the cytosol and thus increases the susceptibility to hydrolysis by lipase(s), resulting in increased basal lipolysis. As a physiological consequence of trans-10,cis-12 CLA supplementation, ADRP replaces perilipin as a lipid droplet-coating protein by CLA’s combined action on the transcriptional repression of perilipin and HSL and the translational activation of ADRP in a mTOR pathway-dependent manner.