TABLE 3.

Concentrations of proinflammatory cytokines in serum at 0, 3, and 7 wk of the high-cholesterol, high-fat diet¹

	0 wk	3 wk	7 wk	P2
TAS (mmol/L)	1.38 ± 0.01	1.41 ± 0.02	1.40 ± 0.02	0.374
CRP (mg/dL)	0.30 ± 0.07	0.27 ± 0.04	0.28 ± 0.02	0.900
RANTES (pg/mL)	115.9 ± 39.1	235.7 ± 28.7	208.4 ± 55.8	0.134
TNFRI (pg/mL)	0.53 ± 0.02	0.49 ± 0.04	0.43 ± 0.04	0.170
TNFRII (pg/mL)	0.59 ± 0.09	0.51 ± 0.0.07	0.29 ± 0.073	0.029
IL-1β (pg/mL)	<3.2	<3.2	<3.2	NA
IL-6 (pg/mL)	15.99 ± 4.0	48.3 ± 5.44	3.4 ± 4.53	0.0001
IL-8 (pg/mL)	131.6 ± 35.6	261.8 ± 41.8	287.7 ± 75.0	0.107
GM-CSF (pg/mL)	6.0 ± 1.8	5.4 ± 0.1	6.6 ± 0.3	0.947
INF-γ (pg/mL)	48.2 ± 12.5	41.3 ± 13.9	44.4 ± 17.6	0.946
MCP-1 (pg/mL)	31.5 ± 2.1	41.8 ± 4.63	52.5 ± 4.34	0.003
TNF-α (pg/mL)	8.0 ± 8.5	16.0 ± 3.53	1.2 ± 0.63	0.048
sVCAM-1 (ng/mL)	425.3 ± 2.8	425.8 ± 3.1	419.1 ± 3.2	0.246
sICAM-1 (ng/mL)	2.6 ± 0.8	2.5 ± 0.8	2.0 ± 0.7	0.840

¹All values are $\overline{x}\pm \text{SEM}$; n = 10 baboons. TAS, total antioxidant status; CRP, C-reactive protein; RANTES, regulated on activation normal T cell expressed and secreted factor; TNFRI, tumor necrosis factor α receptor I; INFRII, TNF-α receptor II; IL, interleukin; GM-CSF, granulocyte macrophage colony-stimulating factor; INF-γ, interferon γ; MCP-1, monocyte chemoattractant protein 1; TNF-α, tumor necrosis factor α; sVCAM-1, soluble vascular cell adhesion molecule 1; sICAM-1 soluble intercellular cell adhesion molecule 1.

²ANOVA.

^3,4Significantly different from 0 wk (ANOVA with post hoc Bonferroni correction for between-group comparisons):

³P < 0.05,

⁴P < 0.01.