TABLE 6.

Changes in secreted soluble inflammatory markers in baboon femoral artery endothelial cells challenged in vitro¹

	In vitro stimulus
Cytokine	No treatment	TNF-α	LPS	Native LDL	oxLDL
IL-6
0 wk	6.9 ± 1.7	10.5 ± 2.42	10.3 ± 2.42	5.1 ± 1.6	6.2 ± 1.5
7 wk	5.8 ± 1.1	7.9 ± 0.9	8.6 ± 1.1	5.3 ± 2.0	4.3 ± 0.6
IL-8
0 wk	0.12 ± 0.32	12.8 ± 2.13	9.1 ± 3.32	2.4 ± 2.2	2.1 ± 1.9
7 wk	0.1 ± 0.04	6.5 ± 0.64	4.8 ± 0.94	0.1 ± 0.02	0.17 ± 0.08
GM-CSF
0 wk	<0.01	0.25 ± 0.12	0.11 ± 0.06	<0.01	<0.01
7 wk	<0.01	0.1 ± 0.013	0.03 ± 0.012	<0.01	<0.01
INF-γ
0 wk	<0.01	<0.01	<0.01	<0.01	<0.01
7 wk	<0.01	<0.01	<0.01	<0.01	<0.01
MCP-15
0 wk	0.35 ± 0.08	12.02 ± 2.44	7.0 ± 2.12	1.4 ± 0.53	0.85 ± 0.30
7 wk	0.70 ± 0.14	7.35 ± 0.774	6.9 ± 1.13	1.6 ± 1.2	2.18 ± 1.26
RANTES
0 wk	<0.01	<0.01	<0.01	<0.01	<0.01
7 wk	<0.01	<0.01	<0.01	<0.01	<0.01

¹All values are $\overline{x}\pm \text{SEM}$, n = 10 baboons. TNF-α, tumor necrosis factor α; LPS, lipopolysaccharide; oxLDL, oxidized LDL; IL, interleukin; GM-CSF, granulocyte-macrophage colony-stimulating factor; INF-γ, interferon γ; MCP-1, monocyte chemoattractant protein 1; RANTES, regulated on activation normal T cell expressed and secreted factor.

^2–4Significantly different from no treatment at the same week (paired Student’s t test) with Bonferroni correction for multiple comparisons:

²P < 0.05,

³P < 0.01,

⁴P < 0.001.

⁵There was a significant time-by-treatment interaction only for MCP-1 concentrations in endothelial cell treated with TNF-α based on 2-factor ANOVA.