Table 2.

Summary of previously reported urachal neuroendocrine carcinoma cases and clinical outcomes

Author	Sex	Age	Sheldon Stage	LNM	Metastasis	Surgical resection	Cystectomy	Urethrectomy	PLND	Umbilical fusion resection	RT	Histopathology	CGP	Outcome
Obiedat S [6]	Male	33	Ⅳ	Yes	Lung, Bone, Liver	No	No	No	No	No	Yes	60% ADE and NEC	None	Unknown
Ebara S [7]	Male	32	Ⅲ	No	Lung, Bone, Local	Yes	Partial	No	Yes	Unknown	Yes	ADE and SCC	None	Unknown
Wang G [8]	Male	23	ⅢA	Yes	Lung, Pleura	Yes	Partial	No	Yes	Yes	No	ADE and SCC (70%)	None	Developed widespread metastases at 21 mo
	Female	25	ⅣA	Yes	Brain, Lungs, Liver	Yes	Partial	No	Yes	Yes	Yes	ADE and LCC	None	Died at 31 mo
	Male	34	ⅣA	Yes	Liver, Spine, Local	Yes	Partial	No	Yes	Yes	Yes	ADE and SCC	None	Died at 10 mo
Paner GP [1]	Female	56	ⅣA	Yes	Lungs, Spine, Mediastinum	Yes	Partial	No	Yes	Unknown	No	UC in situ and SCC	None	Died at 18 mo
	Male	64	ⅢA	No	Spine	Yes	Radical	Unknown	Yes	Unknown	Yes	SCC	None	Died at 24 mo
Johnson DE [9]	Female	76	Ⅲ	No	No	Yes	Partial	No	Unknown	Yes	No	ADE and SCC	None	Alive at 72 mo
Munichor M [10]	Male	53	Ⅲ	No	No	Yes	Partial	No	Yes	Yes	No	ADE and SCC	None	Unknown
Abenoza P [11]	Male	55	Ⅳ	Yes	Ureters, Lungs, Brain, Liver, Bone	Yes	Radical	Unknown	Yes	Unknown	No	ADE and LCC	None	Died 30 mo after first examination
Hom JD (12)	Female	31	Unknown	Yes	Liver, Bones	Yes	Partial	No	Yes	Yes	No	ADE and SCC	None	Died 3 mo after surgery
Our case	Male	38	ⅣB	Yes	Lung	Yes	Partial	No	Yes	Yes	No	LCC	Yes	Alive at 9 mo after surgery

LNM lymph node metastasis, PLND pelvic lymph node dissection, RT radiation therapy, CGP comprehensive genomic profiling, ADE adenocarcinoma, NEC neuroendocrine carcinoma, SCC small cell carcinoma, LCC large cell carcinoma, UC urothelial carcinoma, mo months