Table 1.

Case reports of anal canal adenocarcinoma with pagetoid spread treated with CCRT or RT

Author (year of publication)	Patient sex, age (years)	Radiation dose	Chemotherapy	Follow-up duration (months)	Outcome	Anal function
Sakata et al. (1994) [5]	M, 86	40 Gy/2 Gy	Concurrent doxifluridine 800 mg + 5-FU ointment	9	NED	Preserved
Shimizu et al. (2003) [6]	M, 59	60 Gy/2 Gy	Adjuvant FOLFIRI	5	AWD	Not mentioned
Apikotoa et al. (2022) [7]	F, 76	54 Gy/1.8 Gy	Concurrent capecitabine, adjuvant FOLFOX	12	NED	Preserved

M male, F female, NED no evidence of disease, AWD alive with disease, CCRT concurrent chemoradiation therapy