Table 2.
Comparison of the effects on sperm in response to AGTPBP1/Agtpbp1 mutations in humans and mice
| Cases with mutated AGTPBP1 R811H | Agtpbp1del/del mice | Agtpbp1R791H/R791H mice | |
|---|---|---|---|
| AGTPBP1 amount | Decreased AGTPBP1 | Loss of AGTPBP1 | N/A |
| Sperm concentration | 12 × 106 (WHO ref limit:15 × 106) | 4.7 × 105 (WT:184.3 × 105) | Normal |
| Sperm motility | 31% (WHO ref limit: 40%) | 6% (WT: 46%) | Normal |
| Normal sperm morphology | 3% (WHO lower limit: 4%) | 3% (WT: 76%) | 61% (WT:70%) |
| Deglutamylase enzymatic activity | N/A | Decreased | N/A |
| Delta (△)−2 tubulin amount | N/A | Decreased | N/A |
N/A not available, WT wild-type