Table 1.
Baseline levels of IFN-γ (pg/mL) in plasma and in response to mycobacterial challenge from 1–18 years old (yo). Values are presented as median and interquartile range (Q1–Q3)
| Stimulation condition |
1–3 yo (N = 9) |
> 3–5 yo (N = 6) |
> 5–7 yo (N = 9) |
> 7–10 yo (N = 14) |
> 10–14 yo (N = 6) |
> 14–18 yo (N = 8) |
Correlation with age (r) |
p-value |
|---|---|---|---|---|---|---|---|---|
| Plasma |
0.0 (0.0–0.0) |
0.0 (0.0–0.0) |
0.0 (0.0–8.8.0.8) |
0.0 (0.0–0.0) |
0.0 (0.0–0.0) |
15.8 (1.0–31.9.0.9) |
0.18 | 0.23 |
| SR: BCG |
232.8 (113.8–539.1.8.1) |
355.4 (207.3–521.3.3.3) |
498.3 (197.2–568.0) |
161.4 (78.2–840.3.2.3) |
112.3 (57.0–407.5.0.5) |
326.0 (295.3–773.7.3.7) |
−0.01 | 0.93 |
| SR: BCG + IL-12 |
12072.3 (7042.1–34227.0.1.0) |
16876.2 (12017.3–20706.4.3.4) |
17857.8 (9347.2–34417.7.2.7) |
14173.1 (3643.0–22821.8.0.8) |
12551.6 (7573.0–17662.5.0.5) |
11858.4 (8589.3–16865.7.3.7) |
−0.18 | 0.23 |
| SR: PMA + Ionomycin |
37759.3 (35288.5–41540.0.5.0) |
52225.9 (45106.9–63311.4.9.4) |
48454.5 (38035.8–62179.4.8.4) |
56729.2 (39164.4–67188.4.4.4) |
52165.5 (28925.1–72507.1.1.1) |
64205.4 (48021.7–76122.1.7.1) |
0.33 | 0.03 |
| Co-SR: BCG + IL-12 |
100.9 (92.5–104.3.5.3) |
35.5 (31.0–66.1.0.1) |
48.7 (36.1–62.2) |
78.0 (42.7–120.6.7.6) |
78.4 (39.9–125.0) |
29.0 (21.7–41.6) |
−0.23 | 0.18 |
Abbreviations: BCG: SR: stimulation ratio (stimulated condition/basal condition); Co-SR (BCG plus IL-12/BCG). Spearman correlation (r): low association 0.1–0.3; moderate positive association between 0.3–0.5; and strong positive association 0.5–1.5. Statistical significance p < 0.05