TABLE 2.

Colony-forming units of M. avium subsp. paratuberculosis and M. avium subsp. avium after incubation of 10⁷ organisms in vitro with approximately 10⁶ bovine monocyte-derived macrophages for 48 or 96 h^a

Strain	Treatment	Mean count (107 CFU) (% change)
		48 h	96 h
M. avium subsp. paratuberculosis	None	0.98, 1.04, 1.09 (103)	1.00, 1.04, 1.13 (106)
	IFN-γ	0.94, 1.19, 1.04 (106)	0.87, 1.06, 1.13 (102)
M. avium subsp. avium	None	0.76, 0.88, 0.83 (82)	0.36, 0.61, 0.53 (50)*
	IFN-γ	0.67, 0.84, 0.85 (78)	0.20, 0.49, 0.54 (41)*

^aValues represent means of three replicate cultures for each of three cows. Values in parentheses represent percent change for all three cows compared to time zero samples. *, statistically different (P < 0.05) from time zero values.