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. 2026 Jan 12;12:1722081. doi: 10.3389/fnut.2025.1722081

Table 8.

Comparison of the cumulative days of each symptom during the intake period (middle-aged participants).

Symptoms Group 1–4 W 1–8 W 1–12 W
Without With p-value Without With p-value Without With p-value
Runny nose Placebo 1,485 223 <0.001* 2,898 518 <0.001* 4,367 757 <0.001*
LG2055 1,526 350 3,069 683 4,662 966
Nasal congestion Placebo 1,539 169 0.080 3,041 375 0.042* 4,527 597 <0.001*
LG2055 1,722 154 3,395 357 5,112 516
Sneezing Placebo 1,577 131 0.039* 3,039 377 <0.001* 4,519 605 <0.001*
LG2055 1,765 111 3,449 303 5,131 497
Sore throat Placebo 1,589 119 <0.001* 3,169 247 <0.001* 4,775 349 <0.001*
LG2055 1,654 222 3,398 354 5,095 533
Hoarseness Placebo 1,635 73 <0.001* 3,261 155 <0.001* 4,905 219 <0.001*
LG2055 1,842 34 3,666 86 5,470 158
Cough Placebo 1,570 138 <0.001* 3,155 261 <0.001* 4,722 402 <0.001*
LG2055 1,783 93 3,587 165 5,371 257
Headache Placebo 1,619 89 0.703 3,231 185 0.002* 4,843 281 <0.001*
LG2055 1,784 92 3,606 146 5,421 207
General malaise Placebo 1,646 62 0.269 3,271 145 0.953 4,905 219 0.329
LG2055 1,794 82 3,594 158 5,409 219
Chills Placebo 1,671 37 0.385 3,327 89 0.400 5,009 115 0.643
LG2055 1,826 50 3,666 86 5,510 118
Feverishness Placebo 1,690 18 0.137 3,380 36 0.469 5,069 55 0.999
LG2055 1,865 11 3,719 33 5,567 61
Fatigue Placebo 1,588 120 0.607 3,174 242 0.544 4,745 379 0.151
LG2055 1,735 141 3,500 252 5,252 376
Feeling unwell Placebo 1,666 42 0.751 3,325 91 0.882 5,005 119 0.079
LG2055 1,826 50 3,655 97 5,466 162

*Significant difference between the two groups (p < 0.05).