Table 2.
Summary of ferroptosis-in-AD studies and checkpoint linkage.
| Study | Model | Markers measured (GPX4/SLC7A11, ACSL4/LPCAT3, LPO, Fe2+) | Selective rescue (Fer-1/Lip-1) | Checkpoint linkage | Outcome |
|---|---|---|---|---|---|
| Li et al. (2022) | APP/PS1 mouse | GPX4↓ ACSL4↑ LPO↑ Fe2+↑ | Fer-1 ✓ | Iron export defect | Memory ↑ |
| Thorwald et al. (2025) | Human neurons (PSEN mutant) | GPX4↓ ACSL4↑ | Fer-1/Lip-1 ✓ | Presenilin mutation | Cell death ↓ |
| Boshuizen et al. (2020) | Aβ neurons | GPX4↓ LPO↑ Fe2+↑ | Fer-1 ✓ | Mitochondrial dysfunction | Viability ↑ |
| Rouault (2013) | Human/neuron | GPX4↓ LPO↑ Fe2+↑ | Fer-1 ✓ |
This table helps readers visualize where ferroptosis has been directly demonstrated, which hallmarks remain untested, and how these findings connect (or fail to connect) with checkpoint-related mechanisms in AD.