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. 2005 Nov 15;2(12):e381. doi: 10.1371/journal.pmed.0020381

Figure 1. Alveolar CD11b+ Cells Over-Express DC-SIGN in Patients with TB.

Figure 1

(A) BAL cells from a patient with TB (upper four panels) and from a patient with sarcoidosis (lower two panels) were analyzed by flow cytometry. Expression of CD3 and CD4 was analyzed on cells from R1. CD11b and DC-SIGN expression was analyzed on cells from R2.

(B) Distribution of the proportion of CD11b+DC-SIGN+ cells in BALs according to pathology and age. Black circles indicate ≤15 y of age; black triangles indicate ≥20 y; NC, no case.

(C) DC-SIGN (upper panels) and M. tuberculosis (lower panels) immunodetection in serial sections of a lung biopsy from a patient with TB. The pictures are representative of results obtained with samples from a total of four patients. G, granuloma.

(D) DC-SIGN immunodetection in a lung biopsy from a patient with sarcoidosis. The pictures are representative of results obtained with samples from a total of three patients.

In (C) and (D), magnification in left panels is 100×, and regions in squares are shown at higher magnification in right panels.