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. 2005 Oct 31;102(45):16315–16320. doi: 10.1073/pnas.0506190102

Fig. 1.

Fig. 1.

TLR agonists alone are sufficient to induce LN hypertrophy. (A) The number of cells in popliteal LN was measured in WT or TLR9-/- mice (n = 4 per condition) 4 days after footpad injection of TLR ligands in saline. (B) The number of cells in popliteal LN was measured in WT, TLR9-/-, or TLR2-/- mice (n = 3 per condition) 4 days after footpad injection of TLR ligands with or without OVA323–339 peptide in IFA. (C) The total cell number of dLNs (inguinal and iliac) after ivag HSV-2 (106 PFU) infection was measured at the indicated time points. (D) Photographic depiction of dLNs of HSV-2-infected mice. Similar results were obtained in five separate experiments. *, P < 0.05, significant difference between the indicated groups.