Table 2. Univariate Linear Regression Analysis for the Percentage Change in the DTI-ALPS Index after WBRT.
| Variable | Coefficient | Standard error | p |
|---|---|---|---|
| Age | -0.157 | 0.119 | 0.191 |
| Sex | 0.349 | 2.737 | 0.899 |
| Hypertension | -3.988 | 3.186 | 0.217 |
| Diabetes mellitus | -2.235 | 4.933 | 0.652 |
| Primary lung cancer | -1.799 | 2.751 | 0.516 |
| Prior systemic therapy | -1.616 | 3.483 | 0.645 |
| Tyrosine-kinase inhibitor treatment | 2.413 | 3.641 | 0.511 |
| Radiation boost | -2.457 | 3.120 | 0.435 |
| WBRT dose (25 Gy vs. 30 Gy) | -1.013 | 2.687 | 0.708 |
| Total radiation dose | 0.001 | 0.004 | 0.866 |
| Hippocampal avoidance | -1.247 | 3.135 | 0.693 |
| Post-WBRT MRI scan interval | -0.057 | 0.077 | 0.463 |
| Baseline DTI-ALPS index | -11.768 | 4.996 | 0.023 |
DTI-ALPS, diffusion tensor imaging analysis along the perivascular space; WBRT, whole-brain radiotherapy; MRI, magnetic resonance imaging.