Table 3. Univariate and Multivariate Logistic Regression Analyses for the Development of Radiation-Induced LEP on 6-Month Follow-Up T2 FLAIR Images in Subgroup 2.

Variable	Univariate analysis			Multivariate analysis
	Coefficient	Standard error	p	Coefficient	Standard error	p
Age	0.100	0.049	0.041	0.110	0.076	0.146
Sex	-0.760	0.806	0.346
Hypertension	1.050	0.927	0.258
Diabetes mellitus	0.154	1.288	0.905
Primary lung cancer	2.284	1.134	0.044	2.292	1.591	0.150
Prior systemic therapy	-1.492	0.894	0.095	-2.572	1.801	0.153
Tyrosine-kinase inhibitor treatment	1.504	1.012	0.137
Radiation boost	1.371	1.147	0.232
WBRT dose (25 Gy vs. 30 Gy)	0.087	0.758	0.909
Total radiation dose	0.001	0.001	0.430
Hippocampal avoidance	-0.194	0.838	0.817
Baseline DTI-ALPS index	0.058	1.370	0.966
Percentage change in DTI-ALPS index	-0.097	0.049	0.048	-0.194	0.098	0.048
Baseline Fazekas score	1.271	0.592	0.032	0.244	1.014	0.810

DTI-ALPS, diffusion tensor imaging analysis along the perivascular space; LEP, leukoencephalopathy; T2 FLAIR, T2-weighted fluid-attenuated inversion recovery; WBRT, whole-brain radiotherapy.