Fig. 6.

Open-field motor scores after injury show dose-, time-, and route-dependency of EPO. (Left) For single doses delivered i.p. both 5,000 units/kg-bw and 500 units/kg-bw were significantly better than saline, whereas 100 units/kg-bw was not. (Center) Although EPO (5,000 units/kg-bw) administered up to 48 h after injury was associated with a significantly better motor score for the first 3 weeks after injury, by 28 days, 24- and 48-h delays in treatment were not different from saline. (Right) EPO administered i.v. at a lower dose of 500 units/kg-bw was significantly better than the same dose administered i.p.