Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2026 Jan 13;12:1720646. doi: 10.3389/fmed.2025.1720646

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2026 Huang, Huang, He, Zhang, Liu, Li, Yuan, Yang and Zeng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Three graphs display the restricted cubic spline regression analysis of uric acid to HDL-C ratio (UHR) and stroke. Each graph shows odds ratios with 95% confidence intervals against UHR for different models: crude, model 1, and model 2. Histograms show UHR distribution. Red lines with shaded areas indicate spline fits with P-values for overall and nonlinear significance. Each model has its own specific P-values, with the crude model showing P for overall less than 0.001, and model 2 showing P for overall 0.006. — Dose-response relationship between the Uric acid to high-density lipoprotein cholesterol ratio (UHR) and stroke odds. (a) Crude model (unadjusted). (b) Partially adjusted model (adjusted for sex, age, and race). (c) Fully adjusted model (additionally adjusted for BMI, smoking, drinking, hypertension, diabetes, and coronary heart disease). P-values for the overall correlation and the non-linearity test are displayed within each panel.