Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1977 Apr;266(2):453–469. doi: 10.1113/jphysiol.1977.sp011777

Body fluid changes which influence drinking in the water deprived rat.

D J Ramsay, B J Rolls, R J Wood
PMCID: PMC1283575  PMID: 857006

Abstract

1. After overnight deprivation of water both the cellular and extracellular fluid volumes are significantly reduced in the rat. 2. In the rat with functional kidneys oral, intragastric or intravenous preloads of 10 ml. water reduce the total water intake after 1 hr by 64-69%. These preloads restore plasma osmolality to pre-deprivation levels but have little effect on plasma volume. 3. In the same rats if the plasma volume is restored with an oral, intragastric or intravenous preload of 10 ml. of an isotonic balanced salt solution which has little effect on osmolality, drinking is significantly reduced by 20-26%. The reduction of drinking correlated with the volume of the preload of balanced salt. 4. Plasma analysis shown that 1 hr after an oral preload of 10 ml. isotonic balanced salt solution, the extracellular fluid volume of the deprived rats is restored to pre-deprivation levels but osmolality is unchanged. Three hr after the balanced salt preload, extracellular fluid volume is still at pre-deprivation levels and there has been a slight decrease in osmolality due to excretion of salt. 5. In rats which had been nephrectomized or had the ureters ligated so there could be no renal modification of the preloads, the effects of the preloads of water and balanced salt are the same as in rats with intact kidneys. 6. The results indicate that after water deprivation in the rat, changes in both the cellular and extracellular fluid compartment are stimuli to drinking.

Full text

PDF
453

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blass E. M., Epstein A. N. A lateral preoptic osmosensitive zone for thirst in the rat. J Comp Physiol Psychol. 1971 Sep;76(3):378–394. doi: 10.1037/h0031371. [DOI] [PubMed] [Google Scholar]
  2. Blass E. M., Fitzsimons J. T. Additivity of effect and interaction of a cellular and an extracellular stimulus of drinking. J Comp Physiol Psychol. 1970 Feb;70(2):200–205. doi: 10.1037/h0028716. [DOI] [PubMed] [Google Scholar]
  3. Blass E. M., Hall W. G. Behavioural and physiological bases of drinking inhibition in water deprived rats. Nature. 1974 May 31;249(456):485–486. doi: 10.1038/249485a0. [DOI] [PubMed] [Google Scholar]
  4. Buggy J., Fisher A. E. Anteroventral third ventricle site of action for angiotensin induced thirst. Pharmacol Biochem Behav. 1976 Jun;4(6):651–660. doi: 10.1016/0091-3057(76)90216-1. [DOI] [PubMed] [Google Scholar]
  5. Corbit J. D. Effect of hypervolemia on drinking in the rat. J Comp Physiol Psychol. 1967 Oct;64(2):250–255. doi: 10.1037/h0088048. [DOI] [PubMed] [Google Scholar]
  6. Corbit J. D., Tuchapsky S. Gross hypervolemia: stimulation of diuresis without effect upon drinking. J Comp Physiol Psychol. 1968 Feb;65(1):38–41. doi: 10.1037/h0025401. [DOI] [PubMed] [Google Scholar]
  7. Epstein A. N., Fitzsimons J. T., Rolls B. J. Drinking induced by injection of angiotensin into the rain of the rat. J Physiol. 1970 Sep;210(2):457–474. doi: 10.1113/jphysiol.1970.sp009220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. FITZSIMONS J. T. The effects of slow infusions of hypertonic solutions on drinking and drinking thresholds in rats. J Physiol. 1963 Jul;167:344–354. doi: 10.1113/jphysiol.1963.sp007154. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Fitzsimons J. T., Oatley K. Additivity of stimuli for drinking in rats. J Comp Physiol Psychol. 1968 Oct;66(2):450–455. doi: 10.1037/h0026338. [DOI] [PubMed] [Google Scholar]
  10. Fitzsimons J. T. The role of a renal thirst factor in drinking induced by extracellular stimuli. J Physiol. 1969 Apr;201(2):349–368. doi: 10.1113/jphysiol.1969.sp008760. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hall W. G., Blass E. M. Orogastric, hydrational, and behavioral controls of drinking following water deprivation in rats. J Comp Physiol Psychol. 1975 Oct;89(8):939–954. doi: 10.1037/h0077162. [DOI] [PubMed] [Google Scholar]
  12. Hatton G. I., Bennett C. T. Satiation of thirst and termination of drinking: roles of plasma osmolality and absorption. Physiol Behav. 1970 Apr;5(4):479–487. doi: 10.1016/0031-9384(70)90254-4. [DOI] [PubMed] [Google Scholar]
  13. Kucharczyk J., Assaf S. Y., Mogenson G. J. Differential effects of brain lesions on thirst induced by the administration of angiotensin-II to the preoptic region, subfornical organ and anterior third ventricle. Brain Res. 1976 May 28;108(2):327–337. doi: 10.1016/0006-8993(76)90189-x. [DOI] [PubMed] [Google Scholar]
  14. O'KELLY L. I., FALK J. L. Water regulation in the rat: II. The effects of preloads of water and sodium chloride on the barpressing performance of thirsty rats. J Comp Physiol Psychol. 1958 Feb;51(1):22–25. doi: 10.1037/h0046012. [DOI] [PubMed] [Google Scholar]
  15. OATLEY K. CHANGES OF BLOOD VOLUME AND OSMOTIC PRESSURE IN THE PRODUCTION OF THIRST. Nature. 1964 Jun 27;202:1341–1342. doi: 10.1038/2021341a0. [DOI] [PubMed] [Google Scholar]
  16. Rolls B. J., Jones B. P. Cessation of drinking following intracranial injections of angiotensin in the rat. J Comp Physiol Psychol. 1972 Jul;80(1):26–29. doi: 10.1037/h0032821. [DOI] [PubMed] [Google Scholar]
  17. Rolls R. J., McFarland D. J. Hydration releases inhibition of feeding produced by intracranial angiotensin. Physiol Behav. 1973 Dec;11(6):881–884. doi: 10.1016/0031-9384(73)90284-9. [DOI] [PubMed] [Google Scholar]
  18. Simpson J. B., Routtenberg A. Subfornical organ: site of drinking elicitation by angiotensin II. Science. 1973 Sep 21;181(4105):1172–1175. doi: 10.1126/science.181.4105.1172. [DOI] [PubMed] [Google Scholar]
  19. Stricker E. M. Inhibition of thirst in rats following hypovolemia and-or caval ligation. Physiol Behav. 1971 Apr;6(4):293–298. doi: 10.1016/0031-9384(71)90158-2. [DOI] [PubMed] [Google Scholar]
  20. Stricker E. M. Osmoregulation and volume regulation in rats: inhibition of hypovolemic thirst by water. Am J Physiol. 1969 Jul;217(1):98–105. doi: 10.1152/ajplegacy.1969.217.1.98. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES