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Value tree of the benefit and risk criteria. AE, adverse event; ECG, electrocardiogram; GI, gastrointestinal; QoL, quality of life; QLQ-C30, Quality of Life Questionnaire Physical Functioning, Pain, and Appetite Loss subscales. ECG QT prolongation is based on grade ≥2 events of standard MedDRA query (broad-scope search) of torsade de pointes/QT prolongation. GI events: any grade of diarrhea, retching and vomiting, or grade ≥2 nausea; fatigue events: grade ≥2 asthenia or fatigue.
