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. 1977 Aug;269(3):669–676. doi: 10.1113/jphysiol.1977.sp011921

The control of shivering and non-shivering thermogenesis in the rat.

M Banet, H Hensel
PMCID: PMC1283732  PMID: 894609

Abstract

1. The effect of intraperitoneal administration of propranolol (4, 8 and 12 mg/kg) on colonic temperature was studied in twelve rats during exposure to ambient temperatures of 30, 15 and 5 degrees C. 2. At 30 degrees C, propranolol had no effect on colonic temperature; at 15 and 5 degrees C, however, 4 mg propanolol/kg induced a fall in colonic temperature of about 0-8 degrees C, whereas 8 and 12 mg propanolol/kg induced a fall of about 1-5-2-0 degrees C. 3. Assuming that the temperature regulations system of the rat has a proportional controller and that the effect of propranolol was due to the blockade of non-shivering thermogenesis, the results are interpreted as showing that shivering is activated only when heat loss exceeds the capacity for non-shivering thermogenesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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