Fig. 6.

Hypothetic effect of LRRK2 G2019S mutation on kinase activity. (A) Protein alignment of the activation segment of known protein kinase. Red amino acids represent alterations in the bRaf protein that overactivate corresponding kinase activity and predispose to cancer. Green amino acids represent PD-linked mutations in LRRK2. Amino acids in bold represent the conserved protein sequence that defines the activation segment. (B) An ^* indicates the position of the G2019S mutation within the activation segment. The diagram is adapted from ref. 20.