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Change in Sp3 pattern of expression in keratoconus cornea. Western blot, performed on protein extracts of corneas from Fuchs' dystrophy, bullous keratopathy, and keratoconus patients, shows an absence of Sp3 long isoform (arrow) and an overexpression of the Sp3 short isoform(s) (arrowhead) exclusively in keratoconus. Jurkat-cell extracts were used as a control group (Upper). Secondary keratoconus shows an expression profile similar to control cornea (Lower).
