Database	Search Strategy
PubMed/MEDLINE Date: 15 February 2025 Range: 2000–2025 Results: 1247	#1 Population terms: (“ultra high risk”[Title/Abstract] OR “ultra-high risk”[Title/Abstract] OR “clinical high risk”[Title/Abstract] OR “at risk mental state”[Title/Abstract] OR “at-risk mental state”[Title/Abstract] OR “prodromal psychosis”[Title/Abstract] OR “prodrome”[Title/Abstract] OR UHR[Title/Abstract] OR CHR[Title/Abstract] OR ARMS[Title/Abstract]) #2 Neuroimaging terms: (“magnetic resonance imaging”[MeSH Terms] OR MRI[Title/Abstract] OR “functional MRI”[Title/Abstract] OR fMRI[Title/Abstract] OR “diffusion tensor imaging”[Title/Abstract] OR DTI[Title/Abstract] OR “structural imaging”[Title/Abstract] OR “voxel-based morphometry”[Title/Abstract] OR VBM[Title/Abstract] OR “functional connectivity”[Title/Abstract] OR “resting state”[Title/Abstract] OR “resting-state”[Title/Abstract] OR “brain volume”[Title/Abstract] OR “cortical thickness”[Title/Abstract] OR “gray matter”[Title/Abstract] OR “grey matter”[Title/Abstract] OR “white matter”[Title/Abstract] OR “magnetic resonance spectroscopy”[Title/Abstract] OR MRS[Title/Abstract] OR neuroimaging[Title/Abstract]) #3 Outcome terms: (conversion[Title/Abstract] OR transition[Title/Abstract] OR “psychosis onset”[Title/Abstract] OR progression[Title/Abstract] OR “develop psychosis”[Title/Abstract] OR “convert to psychosis”[Title/Abstract] OR predict[Title/Abstract] OR biomarker[Title/Abstract]) #4 Combined: #1 AND #2 AND #3 Filters: English language; 2000–2025; Journal Article
Scopus Date: 15 February 2025 Range: 2000–2025 Results: 1456	TITLE-ABS-KEY ((“ultra high risk” OR “ultra-high risk” OR “clinical high risk” OR “at risk mental state” OR “prodromal psychosis” OR uhr OR chr OR arms) AND (mri OR fmri OR “diffusion tensor” OR dti OR “structural imaging” OR “voxel-based morphometry” OR “functional connectivity” OR “resting state” OR “brain volume” OR “cortical thickness” OR “gray matter” OR “grey matter” OR “white matter” OR spectroscopy OR mrs OR neuroimaging) AND (conversion OR transition OR “psychosis onset” OR progression OR predict OR biomarker) Limiters: PUBYEAR > 1999 AND PUBYEAR < 2026 LIMIT-TO (LANGUAGE, “English”)
Web of Science Date: 15 February 2025 Range: 2000–2025 Results: 982	TS = ((“ultra high risk” OR “ultra-high risk” OR “clinical high risk” OR “at risk mental state” OR “prodromal psychosis” OR UHR OR CHR OR ARMS) AND (MRI OR fMRI OR “diffusion tensor” OR DTI OR “structural imaging” OR “functional connectivity” OR “resting state” OR “brain volume” OR “cortical thickness” OR “gray matter” OR “grey matter” OR “white matter” OR spectroscopy OR MRS OR neuroimaging) AND (conversion OR transition OR “psychosis onset” OR progression OR predict* OR biomarker) Limiters: Timespan: 2000–2025 Language: English Document types: Article
PsycINFO Date: 15 February 2025 Range: 2000–2025 Results: 324	AB ((“ultra high risk” OR “ultra-high risk” OR “clinical high risk” OR “at risk mental state” OR “prodromal psychosis” OR UHR OR CHR OR ARMS) AND (MRI OR fMRI OR “diffusion tensor” OR DTI OR “structural imaging” OR “functional connectivity” OR “resting state” OR “brain volume” OR “cortical thickness” OR “gray matter” OR “white matter” OR spectroscopy OR MRS OR neuroimaging) AND (conversion OR transition OR “psychosis onset” OR progression OR predict OR biomarker) Limiters: Published Date: 20000101–20250215 Language: English Document Type: Journal Article
Cochrane Library Date: 15 February 2025 Range: 2000–2025 Results: 118	(“ultra high risk” OR “clinical high risk” OR “at risk mental state” OR “prodromal psychosis” OR UHR OR CHR OR ARMS):ti, ab, kw AND (MRI OR fMRI OR “diffusion tensor” OR DTI OR neuroimaging OR “brain imaging” OR “structural imaging” OR “functional connectivity”):ti, ab, kw AND (conversion OR transition OR “psychosis onset” OR predict OR biomarker):ti, ab, kw
TOTAL	Total Records from Database Searches: 4127 Additional Records (Reference Lists + Citation Tracking): 23 GRAND TOTAL: 4150 records
	Inter-rater reliability: Cohen’s κ = 0.89 (95% CI: 0.84–0.94) for study selection, indicating excellent agreement between reviewers.