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Category
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Variables Extracted
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Study Identification and Design
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First author and publication year
Country and geographic location
Study design (prospective cohort, retrospective cohort)
Single-site versus multi-site study
Funding source and conflicts of interest
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Participant Characteristics
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Total sample size (UHR participants)
Number of converters and non-converters
Conversion rate (percentage)
Age: mean, standard deviation, and range
Sex distribution (percentage male/female)
Ethnicity and racial composition
UHR criteria used (CAARMS, SIPS/SOPS, Basel, other)
UHR subtype distribution (APS, BLIPS, GRD)
Baseline symptom severity (SIPS, PANSS, CAARMS scores)
Baseline functioning (GAF, SOFAS scores)
Antipsychotic medication status at baseline (%, dosage)
Cannabis use (% users, frequency, lifetime exposure)
Other substance use
Psychiatric comorbidities (depression, anxiety, PTSD)
Family history of psychosis
Educational level
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Neuroimaging Assessment Details
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Scanner manufacturer and model
Magnetic field strength (1.5T, 3T, other)
Imaging modality (sMRI, fMRI, DTI, MRS, multimodal)
Structural MRI sequence parameters (TR, TE, voxel size, slice thickness)
Functional MRI paradigm (task-based: specific task; resting-state: duration)
DTI sequence parameters (number of directions, b-values)
MRS voxel location, size, and metabolites measured
Brain regions assessed (specific regions or whole-brain)
Analysis approach (ROI, VBM, surface-based, tract-based, connectivity)
Software used for image processing and analysis
Quality control procedures
Head motion assessment and correction methods
Artifact detection and exclusion criteria
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Follow-up and Outcome Assessment
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Follow-up duration (months or years)
Conversion assessment method and criteria (DSM-IV/5, ICD-10/11)
Assessment instruments used (SCID, CAARMS, SIPS)
Assessor training and inter-rater reliability
Blinding of assessors to neuroimaging results
Follow-up assessment schedule and frequency
Time to conversion for converters
Specific psychotic disorder diagnoses (schizophrenia, schizoaffective, brief psychotic, other)
Loss to follow-up (number and percentage)
Reasons for attrition
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Results and Effect Sizes
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Neuroimaging measures: means and standard deviations for converters and non-converters
Statistical test results (t-tests, F-tests, Z-scores, p-values)
Effect sizes: Cohen’s d, Hedges’ g, partial eta-squared, other
Confidence intervals for effect sizes
Classification accuracy metrics: sensitivity, specificity
Positive predictive value (PPV) and negative predictive value (NPV)
Area under receiver operating characteristic curve (AUC-ROC)
Likelihood ratios (positive and negative)
Odds ratios and hazard ratios for conversion
Multivariable model results (beta coefficients, p-values)
Machine learning classification performance (accuracy, precision, recall, F1-score)
Cross-validation results
Feature importance or weights from machine learning models
Subgroup analyses (by sex, age, UHR subtype, medication status)
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Statistical Methods and Confounders
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Statistical tests used
Multiple comparison correction methods (FWE, FDR, Bonferroni, other)
Covariates included in analyses:
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Age correction
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Sex as covariate
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Total intracranial volume correction
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Education level adjustment
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Baseline symptom severity adjustment
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Medication exposure correction
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Cannabis use adjustment
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Head motion parameters (for fMRI/DTI)
Handling of missing data
Power calculations and sample size justification
Statistical software used
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Note: All extracted data were entered into a standardized spreadsheet and double-checked for accuracy. Any discrepancies between reviewers were discussed and resolved by re-examining the original source publication. Study authors were contacted when data were missing or unclear, with two reminder emails sent at two-week intervals if no response was received to the initial contact. |