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. 2005 Oct 27;24(22):3952–3962. doi: 10.1038/sj.emboj.7600849

Figure 2.

Figure 2

PR of CPDs is a major determinant of significant gene expression profiles. (A) Tree graph representation of the similarity between significant expression profiles (ANOVA P⩽0.05, ⩾±1.5-fold change) at a given time point. Note the clustering of all matrix points (defined as a unique combination of dose and time point) into two main groups correlating to dark or light exposure during PR (to the left and right of the dotted orange line, respectively). (B) Venn diagrams of 2, 4 and 8 J/m2 biosets. Each bioset represents all significant genes in at least one time point (0–24 h) at the corresponding dose (2, 4 and 8 J/m2) in the absence of PR. (C) CPD-dependent and -independent gene expression. Each bioset from (B) was divided into blue, depicting the percentage of genes shared between both PR and non-PR MDFs (CPD-independent), and red, depicting the percentage of genes present only in the absence of PR (CPD-dependent). (D) Time dependence of the shared transcriptional response. The 8 J/m2 bioset representing all significant genes at each individual time point (−30 min to 24 h) was divided proportionately into blue and red representing CPD-independent and -dependent gene expression, respectively.