ADHD	Attention Deficit Hyperactivity Disorder
ADMET	Absorption, Distribution, Metabolism, Excretion, Toxicity
BBB	blood–brain barrier
BSA	bovine serum albumin
Caco-2	human colorectal cancer cell line
Clint	Clearance
cAMP	3′,5′-cyclic adenosine monophosphate
CYP	cytochrome
DA	dopamine
DCM	dichloromethane
DTLs	dual-target ligands
DX	doxorubicin
ER	efflux ratio
FAD	flavin adenine dinucleotide
FC	flash chromatography
HepG2	human liver cancer cell line
H3R	histamine H3 receptor
hH3R	human histamine H3 receptor
hMAO-A	human monoamine oxidase A
hMAO-B	human monoamine oxidase B
KE	ketoconazole
MAO-B	monoamine oxidase B
MLMs	mouse liver microsomes
MM-GBSA	Molecular Mechanics–Generalized Born Surface Area
NC	negative controls; untreated control
PAMPA	Parallel Artificial Membrane Permeability Assay
Papp	permeability coefficient
PBMCs	peripheral blood mononuclear cells
PBS	phosphate-buffered saline
PC	positive control
PD	Parkinson’s Disease
PEA	β-phenylethylamine
PFA	paraformaldehyde
RLMs	rat liver microsomes
RMSD	Root Mean Square Deviation
ROS	reactive oxygen species
RT	residence time
SAF	Safinamide
SH-SY5Y	human neuroblastoma cell line
SPRM	Surface Plasmon Resonance Microscopy
QD	quinidine