ALS	Amyotrophic lateral sclerosis
ANOVA	Analysis of variance
ASO	Antisense oligonucleotide
BBB	Blood–brain barrier
BSA	Bovine serum albumin
BSCB	Blood-spinal cord barrier
CMAP	Compound motor action potential
CNS	Central nervous system
CSF	Cerebrospinal fluid
DMEM	Dulbecco’s Modified Eagle Medium
EE	Encapsulation efficiency
ELISA	Enzyme-linked immunosorbent assay
FACS	Fluorescence-activated cell sorting
HMC3	Human microglial clone 3
IACUC	Institutional Animal Care and Use Committee
Iba1	Ionized calcium-binding adapter molecule 1
IV	Intravenous
LAT1	L-type amino acid transporter 1
NfL	Neurofilament light chain
NMJ	Neuromuscular junction
PBS	Phosphate-buffered saline
PDI	polydispersity index
PGC-1α	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
qPCR	Quantitative PCR
RT	Room temperature
SOD1	Superoxide dismutase 1
TBS	Tris-buffered saline
TBS-T	TBS with tween 20
WT	Wild-type