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. 2026 Jan 14;27(2):826. doi: 10.3390/ijms27020826
5hmC 5-Hydroxymethylcytosine
5hmdC 5-hydroxymethyl-2′-deoxynytidine
5hmdC Global DNA hydroxy methylation
5mC 5-Methylcytosine
5mdC Global DNA methylation
ARC American College of Rheumatology Criteria
BAI Beck Anxiety Index
BDNF Brain-derived neurotrophic factor
BMI Body mass index
C-CPM Cold effect on conditioned pain modulation
COMT Catecholamine-O-methyltransferase
CpG Cytosine-phosphate-Guanine dinucleotide
CPM Conditioned pain modulation
CPT Cold pain thresholds
CSI Central sensitization inventory
CSL CFS symptom list for ME/CFS-related symptoms
DNA Deoxyribonucleic acid
DNMT3a DNA methyltransferase 3a
EM-Seq Enzymatic methyl-sequencing
FM Fibromyalgia
fMRI Functional magnetic resonance imaging
H-CPM Heat effect on conditioned pain modulation
HDAC1 Histone deacetylase 1
HPLC High-pressure liquid chromatography
HPT Heat pain thresholds
IPAQ International physical activity questionnaire
LC/MS-MS Liquid chromatography and tandem mass spectrometry
MB-COMT Membrane-bound COMT
MBD1 Methyl-CpG-binding domain 1
ME/CFS Myalgic encephalomyelitis/chronic fatigue syndrome
MeCP2 Methyl-CpG-binding proteins
METs Metabolic equivalents
MOR µ-Opioid receptor 1
mRNA Messenger RNA
NRS Numeric Rating Scale
OPRM1 µ-Opioid receptor 1 gene
PCA Principal component analysis
PCR Polymerase chain reaction
PCS Pain catastrophizing scale
PET Positron emission tomography
PPT Pressure pain threshold
QST Quantitative sensory testing
RM-LMM Repeated-measures linear mixed model
S-COMT Soluble COMT
SF-36 Short-form 36 questionnaire
TAPSß TET-assisted pyridine borane sequencing
VIF Variance inflation factor
WPI Widespread Pain Index