| CRC | Colorectal cancer |
| GEM | Genome-Scale Metabolic Model |
| SCFAs | Short-chain fatty acids |
| mGWAS | metabolome-wide genome-wide association study |
| GWAS | Genome-Wide Association Study |
| MR | Mendelian randomization |
| IBD | inflammatory bowel disease |
| FVA | Flux Variability Analysis |
| TPM | Transcripts Per Million |
| KS | Kolmogorov–Smirnov |
| FDR | False Discovery Rate |
| Probability Density Function | |
| FC | flux change |
| CI | confidence interval |
| HMDB | Human Metabolome Database |
| ROS | generating reactive oxygen species |
| GPR | Gene-Protein-Reaction |
| GO | Gene Ontology |
| KEGG | Kyoto Encyclopedia of Genes and Genomes |
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