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. 2026 Jan 13;19(1):137. doi: 10.3390/ph19010137
ALA Alanine
ARG L-Arginine
ARG1 Arginase-1
APO Apo form (unbound protein structure)
BH4 Tetrahydrobiopterin
CVI Chronic Venous Insufficiency
CYS Cysteine
ΔG_binding Gibbs Free Energy of Binding
eNOS Endothelial Nitric Oxide Synthase
EV Eigenvalue
FEL Free Energy Landscape
GLN Glutamine
GLU Glutamic Acid
GLY Glycine
H-Bond Hydrogen Bond
IL-1β Interleukin-1 Beta
IL-6 Interleukin-6
iNOS Inducible Nitric Oxide Synthase
kJ/mol Kilojoules per mole
LPS Lipopolysaccharide
MD Molecular Dynamics
MM-PBSA Molecular Mechanics Poisson–Boltzmann Surface Area
MMP Matrix Metalloproteinase
M1/M2 Macrophage Phenotypes (Pro-inflammatory/Reparative)
NO Nitric Oxide
ONOO Peroxynitrite
PCA Principal Component Analysis
PDB Protein Data Bank
PHE Phenylalanine
PRO Proline
Rg Radius of Gyration
RMSD Root Mean Square Deviation
RMSF Root Mean Square Fluctuation
RNS Reactive Nitrogen Species
ROS Reactive Oxygen Species
SASA Solvent-Accessible Surface Area
STD Standard Inhibitor (1400W)
TNF-α Tumor Necrosis Factor-Alpha
TRP Tryptophan
TYR Tyrosine
TAV Tavaborole
VLU Venous Leg Ulcer