Table 3.

Bivariate relationships with SHASH (change in UACR)

​	​	Variable (baseline data)	R-squared	Adjusted R-squared	RMSE	F value	Intercept estimate	Slope estimate	Slope p value
Continuous data	Covariate factor	SHASH (baseline UACR)	0.223	0.208	0.896	15.204	−0.026	−0.480	<0.001*
		Age	0.005	−0.014	1.014	0.246	0.490	−0.007	0.622
		BMI	0.002	−0.017	1.000	0.130	0.231	−0.010	0.720
		Systolic BP	0.065	0.047	0.983	3.662	2.170	−0.017	0.061
		Diastolic BP	0.051	0.033	0.990	2.838	1.279	−0.018	0.098
		Creatinine	0.041	0.022	0.995	2.241	0.812	−0.956	0.140
		eGFR	0.113	0.096	0.957	6.752	−1.324	0.020	0.012*
		Cystatin C	0.027	0.008	0.995	1.400	0.683	−0.692	0.242
		K	0.002	−0.018	1.020	0.090	−0.498	0.117	0.765
		UA	0.036	0.018	0.998	1.976	0.845	−0.153	0.166
		Triglyceride	0.176	0.160	0.930	11.084	0.348	−0.002	0.002*
		HDL cholesterol	0.064	0.046	0.992	3.528	−1.000	0.019	0.066
		LDL cholesterol	0.005	−0.015	1.022	0.241	−0.285	0.003	0.626
		HbA1c	0.001	−0.018	1.016	0.065	−0.320	0.042	0.800
		Aldosterone	0.003	−0.018	1.035	0.126	0.164	−0.001	0.724
Binary data		Sex	0.010	−0.008	1.011	0.552	N/A	N/A	0.461
		Use of SGLT-2 inhibitor	0.001	−0.018	1.016	0.035	N/A	N/A	0.853

RMSE, root mean square error; SHASH, sinh-arcsinh normal distribution transformation; UACR, urine albumin-creatinine ratio; BMI, body mass index; BP, blood pressure; eGFR, estimated glomerular filtration rate; K, serum potassium; UA, uric acid; HDL, high-density lipoprotein; LDL, low-density lipoprotein; HbA1c, glycated hemoglobin; SGLT-2 inhibitor, sodium-glucose cotransporter 2 inhibitor.

*p < 0.05.