3R	Replacement, Reduction, Refinement
AE	Acceptable exposure
AET	Analytical Evaluation Threshold
AI	Acceptable intake
bDtBPP	bis(2,4-di-tert-butylphenyl)phosphate
BHT	Butylated hydroxytoluene
BPA	Bisphenol A
CHO	Chinese Hamster Ovary
DEHP	Di(2-ethylhexyl) phthalate
DNA	deoxyribonucleic acid
DP	Drug product
DS	Drug substance
EC3	Estimated concentration 3
ECHA	European Chemicals Agency
EDE	Estimated daily exposure
ELSIE	Extractables and Leachables Safety Information Exchange
EMA	European Medicines Agency
EPO	Erythropoietin
EU	European Union
E&L	Extractables and leachables
FDA	Food and Drug Administration
GLP	Good laboratory practice
IgG	Immunoglobulin G
IUPAC	International union of pure and applied chemistry
LOD	Limit of Detection
LOEL	Lowest observed effect level
LOQ	Limit of Quantitation
LTL	Less-than-lifetime
LVP	Large-volume parenterals
MBT	2-Mercapto-benzothiazole
MoS	Margin of safety
NAMs	New Approach Methodologies
NDBA	N-Nitrosodibutylamine
NDMA	N-Nitrosodimethylamine
NOAEL	No observed adverse effect level
NOEL	No observed effect level
OECD	Organization for Economic Co-operation and Development
OINDP	Orally inhaled and nasal drug products
PAHs	Polycyclic aromatic hydrocarbons
PDE	Permitted daily exposure
PDP	Parenteral drug products
PFAS	Per- and polyfluoroalkyl substances
PNAs	Polynuclear aromatic hydrocarbons
POD	Point of departure
PODP	Parenteral and Ophthalmic Drug Product
ppm	Parts per million
PPWR	Packaging and Packaging Waste Regulation
PQRI	Product Quality Research Institute
PRCA	Pure red cell aplasia
PTFE	Polytetrafluoroethylene
PVC	Polyvinyl chloride
REACH	Registration, Evaluation, Authorisation and Restriction of Chemicals
QSAR	Quantitative structure-activity relationship
QT	Qualification threshold
RSD	Relative standard deviation
SAR	Structure–activity relationship
SCT	Safety concern threshold
TD50	Tumorigenic dose 50
TSCA	Toxic Substances Control Act
TTC	Threshold of toxicological concern
UN	United Nations
USP	United States Pharmacopeia
UV	Ultraviolet
V(MDD)	Volume of maximum daily dose