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. 2026 Jan 7;17:1048. doi: 10.1038/s41467-025-67806-1

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — LAG reactions, equilibrium constants, and changes in the reactions’ free energies for three solvation scenarios: a single solvation, b stepwise solvation, and c competing solvation. A is used for the API, S and T for two different solvents and m, n and w for the stoichiometries. (s) and (l) refer to the solid and liquid states, respectively. Activities (α) at equilibrium are indicated with an * superscript.