Fig. 7. Ternary solvent phase diagram for nitrofurantoin determined by CSA-LAG.

CSA-LAG outcomes for nf in a ternary solvent system (h2o, dmf and etoh). Blue marks NF-MH-II (monohydrate), green NF-DMF-II (DMF solvate) and red NF-β (anhydrous). Points indicate experimentally identified forms; colour-mapped regions denote thermodynamically stable phases. Plot shown in mole fraction (not activity), as ${\alpha }_{dmf}+{\alpha }_{h2o}+{\alpha }_{etoh}\ne 1.0$.