Table 2.

Solid form equilibrium reactions investigated using CSA-LAG, with corresponding critical solvent activity ranges measured experimentally and compared to those obtained from slurry experiments using the same solvent mixtures

Type	Equilibrium reaction	Active solvent	Carrier solvent	${\alpha }_S^{*}$
				CSA-LAG (T = 25 ± 1 °C)	Slurriesa (T = 25 °C)
Hydrates	THEO-II + H2O ⇌ THEO-MH-I	h2o	ace	0.50–0.60	0.56–0.6114
	CBZ-III + 2 (H2O) ⇌ CBZ-DH-I	h2o	etoh	0.60–0.70	0.60 $-$0.6359
	NF-β + H2O ⇌ NF-MH-I	h2o	eg	0.45–0.55	0.45–0.55
Solvates	THEO-II + DMSO ⇌ THEO-DMSO-I	dmso	etoh	0.20–0.30	0.20–0.30
	4OHBZM-I + Ace ⇌ 4OHBZM-ACET-I	ace	eg	0.20–0.30	0.20–0.30
	CBZ-III + DMSO ⇌ CBZ-DMSO-I	dmso	etoh	0.20–0.30	0.20–0.30
	NF-β + DMF ⇌ NF-DMF-II	dmf	etoh	0.00–0.10	0.00–0.10

^aCompetitive slurry critical solvent activities were either taken from the literature (citations given) or determined by us. The NF-MH-I equilibrium data in the table was derived by us with a separate similar value existing in the literature (0.43–0.56⁷³).