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. 2026 Jan 14;16:1667066. doi: 10.3389/fpsyt.2025.1667066

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Copyright © 2026 García-Toro and Gómez-Juanes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flowchart illustrating the interaction between stress and vulnerability leading to psychopathology. It features steps like precipitating and predisposing factors, increased activation or excitability, functional inhibitory insufficiency, schismogenesis, hyperactive or hypoactive BPS domains, and resulting psychological outcomes like suffering, maladaptation, and diverse psychopathology. Arrows indicate the progression and interconnections between these steps. — Schismogenesis offers a biopsychosocial (BPS) mechanism that links stress and vulnerability to the emergence of psychopathology.