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. 2026 Jan 21;123(4):e2511733123. doi: 10.1073/pnas.2511733123

Fig. 1.

A multi-part figure shows N Q O 1 m R N A expression in human PDAC and adjacent tissues, preneoplastic stages, and T C G A P A D subtypes.

NQO1 is upregulated in human pancreatic cancer. (A) NQO1 mRNA in human PDAC (n = 50) and adjacent nonmalignant tissues (n = 24) from public datasets (GSE15471, GSE16515). **** Student’s t test, P < 0.0001. (B) NQO1 mRNA across preneoplastic stages (GSE19650): normal ducts, IPMA, IPMN, and IPMC. Kruskal–Wallis, P = 0.0006. (C) NQO1 mRNA in TCGA PDAC (n = 150) showing high expression in Classical subtypes (Moffitt, Collisson) and Progenitor (Bailey); one-way ANOVA, P < 0.0001. (D) Representative NQO1 IHC of PDAC with adjacent nontumor (A, green) and tumor (T, red) regions (dotted line). (Scale bar, 50 µm.) (SI Appendix, Table S1).