Table 1.
BHF Family Heart Study Population Characteristics
|
Findings for Subjects with |
||
| Characteristic | CAD Phenotype | MI Subphenotype |
| No. of study families | 1,933 | 847 |
| No. of affected individuals | 4,175 | 1,776 |
| Percentage of affected males/females | 73.8/26.2 | 77.2/22.8 |
| Mean age, in years (SD), at onset for affected males | 51.7 (7.7) | 50.7 (7.9) |
| Mean age, in years (SD), at onset for affected females | 54.1 (7.4) | 53.4 (7.8) |
| Mean age, in years (SD), at exam for affected individuals | 61.0 (7.4) | 61.6 (7.8) |
| Percentages of subjects, by ethnicity (European/Asian/other) | 98.5/1.4 /.1 | 98.6/1.2/.1 |
| No. (%) of validated and analyzed families, by number of affected siblings: | ||
| Two | 1,675 (86.5) | 772 (91.1) |
| Three | 220 (11.4) | 69 (8.1) |
| More than three | 38 (2.0) | 6 (.8) |
| No. (%) of subjects affected at age <66 years: | ||
| With MI with revascularization (percutaneous coronary intervention/CABG) | 1,365 (32.7) | 937 (52.8) |
| With MI without revascularization | 1,191 (28.5) | 839 (47.2) |
| No. (%) of subjects affected by CAD but not MI at age <66 years: | ||
| CAD with revascularization (percutaneous coronary intervention/CABG) | 1,161 (27.8) | … |
| CAD (angiography or exercise stress test) without revascularization | 458 (11.0) | … |
| No. (%) of subjects with parental history of CAD at age <66 years: | ||
| Neither parent affected | 774 (40.1) | 343 (40.4) |
| Father affected | 617 (31.9) | 260 (30.7) |
| Mother affected | 320 (16.6) | 146 (17.2) |
| Both affected | 221 (11.4) | 98 (11.6) |
| No. (%) of subjects with cardiovascular risk factors: | ||
| Smoking history | 3,051 (73.1) | 1,355 (76.3) |
| Diabetes mellitus (receiving treatment) | 490 (11.7) | 151 (11.8) |
| Hypertension (receiving treatment) | 1,924 (46.1) | 789 (44.4) |
| Hyperlipidemia (>5.0 mmol/liter or receiving treatment) | 3,384 (81.1) | 1,415 (79.7) |
| Obesity (BMI >25 kg/m2) | 3,018 (72.3) | 1,283 (72.2) |