Table 4.
Case-Only Associations of the Y Deletion gr/gr and Family History of TGCT
| gr/grDeletion |
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| Characteristicof TGCT Casesa | n | % | OR (95% CI) | aORb (95% CI) |
| Negative family historyc (n=1,376) | 28 | 2.0 | 1.0 | 1.0 |
| Positive family history (n=431): | 13 | 3.0 | 1.5 (.77–2.9) | 1.7 (.81–3.4) |
| Paternal lineaged (n=345) | 6 | 1.7 | .85 (.35–2.1) | .97 (.38–2.4) |
| Maternal lineaged (n=80) | 7 | 8.8 | 4.6 (2.0–11) | 5.2 (2.1–13) |
a
Information on family history of TGCT was not available for 23 cases. In addition, 12 cases with an affected MZ twin were excluded from analyses of family history.
b
Adjusted for study center (Philadelphia, western Washington State, other North America, Hungary, United Kingdom, and other Europe or Australia).
c
Reference group for all comparisons.
d
Information on six TGCT cases with a family history (one from the ITCLC familial studies and five from the case-control studies) was insufficient to determine the type of Y-chromosome transmission.