Gross pathology of age-matched PBS and phLAL-treated lal−/−;MMR−/− mice. Ventral views (left panel) show the yellow fatty liver in PBS control lal−/−;MMR−/− mice. In phLAL-treated lal−/−;MMR−/− mice, the liver had essentially normal color. Gross view of livers, spleens, kidneys, and mesenteric lymph nodes (right panel, top to bottom) from PBS and phLAL-treated lal−/−;MMR−/− mice. Notice that the color of these organs was nearly normal in phLAL-treated lal−/−;MMR−/− mice.