Figure 7.

Comparison of plasma LAL activity between wild-type and MMR^−/− mice after a single injected dose of hLAL. Age-matched wild-type (lower line) and MMR^−/− (upper line) mice received a single dose (60 μg phLAL per 25 g body weight) via IP injection. Plasma was collected from mice at 0, 5, 20, 30, 45, 60, 75, 90, 105, 120, 180, and 240 min after injection. LAL activities in plasma were determined using 4-MUO as the substrate. Plasma volume was calculated as 3.5% of body weight. The percentage activity remaining in plasma, with respect to input LAL activity, was plotted against time.